The Multi-Compound Approach
Many nutritional immune formulas primarily focus on a single compound vs. a "multi-compound" approach. We believe however, that the beneficial effects of these compounds are greatly enhanced when they are used in combinations, permitting synergistic interactions to occur. RM-10 was specifically created to be a multi-faceted support system for immune disorders.
For much of the last hundred years science has been searching for a cure for cancer, arthritis, and even the common cold. Most of the research has been focused on finding a "magic bullet" in the form of an antibiotic, vaccine or anti-inflammatory. All the while, inside our own body lies the most powerful cure for what ails us, our immune system. The immune system is a person’s primary defense against disease.
Beating Death at 80
||At age 77, Rose Menlowe was diagnosed with cancer. After surgical removal of visible tumors, she declined chemotherapy and radiation, and instead chose to take responsibility for her own well being. Rose began taking RM-10™ for its ability to significantly boost the immune system, enhancing her body's own capacity to control normal cell growth. Rose Menlowe is now cancer-free, and today at age 80, Rose is so full of energy that she has plans to produce an exercise video for seniors - that's how well she is!
What makes the RM-10 formula better than other nutritional immune support formulas?
Unlike other formulas that focus on a single compound, RM-10 uses a multi-compound approach. The beneficial effects of the ingredients in RM-10 are greatly enhanced when used in combinations because of the synergistic interactions that occur. In addition, no other formula can match the bio-availability of the immune-enhancing nutrients in tonic mushrooms. Our propriety Poten-Zyme™ fermentation process provides this superior bio-availability.
A study conducted by Dr. Lawrence Dorman at his Missouri clinic included patients with the most difficult to treat conditions who had not responded to either standard or complementary medicine. The purpose of the study was to assess the efficacy of the RM-10™ formula as a healing modality.
The patients maintained their standard detoxification diet (which consisted of the removal of highly processed and other unhealthful foods). They were taken off of all other nutritional supplements and medications, unless removal of such medications would be considered life threatening. Dr. Dorman gave the patients nine RM-10 caplets per day for 10 days followed by five caplets per day for 80 days as their sole immune support. This was an open-label study. The patients knew they were being given a nutritional formula. Thus, the study allowed for the rise and fall of a placebo effect.
Read the results of the study below.
1.) A 51 year old female, crippled with severe rheumatoid arthritis, suffered joint deformity and severe pain. She experienced a 50-percent decrease in pain and greater flexibility within one week of utilizing RM-10 in her nutritional program.
2.) A 61 year old female with polymyalgia rheumatica had worked with Dr. Dorman for eight months prior to inclusion in the study, showing little or no improvement. Polymyalgia rheumatica causes stiffness and aching that begins in the neck, shoulder, and hip areas. It is not known whether it is a disease of the joints, muscles, or arteries. However, it is thought that inflammation in these areas leads to pain and stiffness. Her walking ease and distance improved by 80 percent and joint pain steadily diminished while on the RM-10™ protocol.
3.) Another 51 year old female with arthritis and irritable bowel syndrome (IBS) experienced complete remission of her IBS and "gradual improvement" in her arthritis.
4.) A 47 year old female with loss of voice, thin vocal chords and hoarseness began using RM-10™. Her symptoms began to disappear with use of nine caplets per day but returned when her dosage was reduced to five. She also experienced better sleep.
5.) In the case of a 31 year old female chronic fatigue syndrome patient, her life had been marked by chronic intermittent myalgia (i.e., muscle pain and soreness), allergies, unremitting fatigue, fever, and sore throat. " She could not accomplish anything with her life because every time she started feeling good, her condition knocked her down again", notes Dr. Dorman. Within eight weeks of placing RM-10™ into her nutritional program, she was feeling better, and has since remained well.
6.) A 60 year old female patient had angina and mixed connective tissue disease. The latter is an autoimmune condition characterized by symptoms of scleroderma, myositis, systemic lupus erythematosus, rheumatoid arthritis and/or other autoimmune disease symptoms, all occurring together. She experienced complete cessation of her angina and marked improvement in her autoimmune condition after one month’s use on RM-10™. In a sense, rather than stimulated, her immune system was "down-regulated" and normalized by the formulation.
7.) A 57 year old female patient with Type II diabetes and chronic fatigue syndrome, began using RM-10™. Within one month, her chronic fatigue syndrome was "virtually gone," says Dr. Dorman, adding that her diabetes was better controlled.
8.) RM-10ô was also beneficial to a 60 year old male with elevated cholesterol and triglycerides, as well as psoriatic skin lesions. Within 10 days, his skin lesions improved by approximately 60 percent. His cholesterol dropped 15 percent and triglycerides by 20 percent within four weeks.
9.) A 37 year old female with colitis, gastritis and food allergies experienced "marked improvement" of her colitis and gastritis within one week of beginning use of RM-10™. Her food allergies also improved significantly.
10.) A 72 year old female with cardiac arrhythmias experienced complete cessation within two weeks of using RM-10™.
11.) A 74 year old male with indigestion, and angina upon exertion began using RM-10™. His indigestion disappeared completely within seven days. His angina improved significantly.
12.) A 57 year old obese female with bilateral knee pain and candidiasis, experienced rapid improvement with the use of RM- 10 in her systemic yeast infection, and modest improvement in her knee pain.
13.) A 46 year old female patient with severe Crohn’s disease improved dramatically (more than 90 percent) after two weeks of use of RM-10, with decreased pain, fewer bowel movements, and less mucous and blood in her stool.
14.) A 51 year old females systemic yeast infection (chronic candidiasis) and allergies improved dramatically after only four weeks on RM-10.
15.) A 19 year-old male with allergies since childhood and seizure disorder, experienced a marked improvement in allergy symptoms within three days use of RM-10. After two weeks, his allergies were virtually gone. He has experienced no additional seizures since starting RM-10™, which may still be considered inconclusive.
16.) An obese 81 year old female with tendonitis and fluid retention began using RM-10™. Her tendonitis was gone within four weeks, and fluid retention 90 percent improved. She lost a small amount of weight.
17.) A 40 year old male with a 10-year history of constipation and only one bowel movement per week, increased his movements to three per week after four weeks of using RM-10™. He reported feeling "much better."
18.) A 47 year old female with psoriasis experienced improvement after four weeks on RM-10™.
19.) A 76 year old female with insomnia and a 30 year history of multiple treatment failures for neuropathy of her feet, reported her insomnia to be gone within two weeks on RM-10™, but did not experience improvement in her neuropathy.
20.) A 38 year old male with a four year history of nausea and vomiting of an unknown etiology, started using RM-10™.
Studies on RM-10
A number of in-vitro studies have been performed by Pierre Braquet, Ph.D., CEO of Bio Inova Life Sciences Laboratories in Paris, France and Montreal, Canada. A noted researcher who studies both pharmaceutical and nutraceutical compounds, Dr. Braquet is credited for his discovery of some of the primary components of the herb Ginko biloba.
According to laboratory results, RM-10:
* Performed notably well in its ability to enhance natural killer cell activity (critical to the body’s healing response to cancer and infectious pathogens). Indeed, according to Dr. Braquet’s associate researcher and board certified immunologist Georges V. Halpern, M.D., Ph.D, "RM10 increases NK cells better than anything else available, and at minimal concentrations."
* Decreases proliferation of malignant cells and causes them to diminish in number.
* Significantly increases function of monocytes (large phagocytic white blood cells that eventually develop into the body’s primary defenders - the macrophages).
* Increases interleukin-1 and modulates interleukin-6. These interleukins are anticancer cytokines that are secreted by activated macrophages. They are produced in response to infection and tissue injury. They stimulate production of antibodies and activate T-cells.
* Modulates production of tumor necrosis factor alpha. Tumor necrosis factor (TNF) is an anti-angiogenic agent that prevents tumors from developing blood vessels for nourishing its growth. In particular, TNF-a specifically initiates a cascade of cytokines that mediate the body’s inflammatory response to infection.
* Appears to be safe to use by persons who suffer from auto immune diseases such as lupus, rheumatoid arthritis, and scleroderma and mediates the body’s healing response. Thus RM10 is not simply an immune stimulant but an immune modulator or normalizer.
* Demonstrates an anti-proliferative effect against K-562 cells. The presence of K-562 cells in the bloodstream is an indicator of leukemia.
Another study conducted at Bio Inova Life Sciences Laboratories evaluated the effectiveness of RM10 and 25 of the top selling immune enhancing products on the market for their ability to enhance immune system function. In this study, researchers looked at natural killer (NK) cells and macrophage function. Natural killer cells roam the bloodstream looking for and destroying foreign-invader cells. Macrophages are large white blood cells that also serve the immune system by killing foreign invaders. In the study, RM-10™ was found to boost the immune system by enhancing the function of natural killer cells and macrophages. RM-10™ out performed virtually every product tested.
In another study at Bio Inova Life Sciences Laboratories, RM-10™ was examined with a view toward how they affect cancer cells. RM-10™ was shown to inhibit the proliferation of cancer cells in the breast, liver and lung.
In an open-label, 90-day clinical pilot study conducted at the Center for Complementary Medicine by Stuart Zoll, O.M.D., researchers tried to find out if RM-10™ could help enhance the health of 20 individuals suffering from various diseases including Hepatitis C. Dr. Zoll found that the majority of patients noticed improved energy, digestion, sleep quality and better resistance to colds and flu. Dr. Zoll concluded, "RM-10™ produces excellent results when used adjunctively with other therapies including it’s use in cancer treatment along with conventional therapies such as chemotherapy and radiation."
In a 120-day, 70-patient, blind placebo-controlled clinical study conducted at the Peoples University of the Americas School of Natural Medicine and directed by Dr. Peter Rothschild, M.D., PhD., and Jesus Garcia, M.D., researchers evaluated the effectiveness of RM-10™ as a primary treatment for Chronic Fatigue Immune Dysfunction Syndrome (CFIDS.) The end results of the study, in general, indicate that RM-10™ caplets qualify as an excellent palliative and/or coadjuvant therapy for Chronic Fatigue Immune Dysfunction Syndrome (CFIDS).
Considering that the target of the study is a pathology that resists all conventional therapeutic methods, it is noteworthy to underscore that approximately 30 percent of the participating test patients did achieve full remission at the conclusion of the study. Moreover, each of the remaining participants did attain varying yet considerable degrees of palliation. Each patient using the RM-10™ formula improved by a minimum of 40 percent after only 120 days of treatment. The placebo effects observed in the control group were completely negligible. Some 23 patients of the original 35 in the control group dropped out of the study because of disappointment, due to total lack of results.
Additional data from studies conducted on RM-10™ showed the following results:
1) Individuals consuming RM-10™ with abnormal immune markers showed a trend towards a modulation of the immune system as evidenced by a decrease in white blood cells, increases in immunoglobulin G and neutrophils, normalization of lymphocytes and natural killer cells, and a decrease in elevated basophils.
2) Individuals with elevated uric acid showed a marked decrease. High levels of uric acid are characteristic of over acidity of the joints and tissues which can lead to joint and muscle pain.
In addition, a significant number of beneficial observations were made in the course of the studies. These were beyond the scope of the established protocol and therefore were not incorporated into the official reports published in Progress in Nutrition:
* Three patients (two females, one male) suffered from sinus infections which disappeared by the beginning of the third month of treatment with RM-10™.
* Twelve patients (eight females, four males) reported remarkable increases in energy levels beginning toward the end of the second month and continuing through the third month of treatment.
* Eleven patients (six females, five males) having suffered from chronic, recurrent migraine headaches, reported total remission from their headaches by the end of the study.
* Five female patients reported significant vanishing of some of their facial wrinkles by the end of the study.
**These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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