Anticancer Res 1996 May-Jun;16(3A):1213-8

Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum
against a non-small-cell bronchopulmonary carcinoma line.

Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin
C, Durand P, Roussakis C. ISOMer (Institut des Substances et Organismes de la Mer), SMAB,
Laboratoire de Pharmacologie Marine, Faculte de Pharmacie, Nantes, France.

Fucans, sulfated polysaccharides extracted from brown seaweeds, have been shown to be
endowed with inhibitory effects cell growth in various experimental models. We studied both the
antiproliferative and antitumor properties of a fucoidan extract (HF) obtained from the brown
seaweed Ascophyllum nodosum on a cell line derived from a non-small-cell human
bronchopulmonary carcinoma (NSCLC-N6); this type of carcinoma is particularly chemoresistant.
HF exerts in vitro a reversible antiproliferative activity with a block observed in the G1
phase the cell cycle. Studies performed with the NSCLC-bearing nude mice show antitumor
activity at subtoxic doses. These preliminary results indicate that HF exhibits inhibitory effect both
in vitro and in vivo and is very potent antitumor agent in cancer therapy.
PMID: 8702239, UI: 96273150

U-FN